Fifty years have passed since Jonathan Joestar fought the Stone Mask Vampire, Dio Brando. Now his grandson Joseph comes to New York, following news of his grandfather's associates. This leads him into adventures in Mexico, Rome and the Alps, fighting the creatures that prey upon vampires — the Pillar Men, Santana, Wham, AC/DC and Cars. And because it's 1938, there are of course Nazis.
This is more of the pulp adventure Boys' Own stuff that we saw in the previous story, with the same gusto and even more outrageous super powered brawling, underground catacombs, Nazi secret bases, car chases, chariot races, damsels in distress, villains who won't stay dead,… Everything and the kitchen sink, really.
Indiana Jones, eat your heart out!